Parasite control changed to highly comprehensive multi-drug oral formulations given monthly (that likewise combat some intensely emerging drug resistance), but it is heavily pushed for several key reasons. Not the least is the emergence of pathogens within Ixodes species ticks, including the Lyme Disease spirochete bacterium, Borrelia, and the very serious parasite Babesia that can transmit very quickly (hours) upon a tick attaching--unlike those organisms carried by the more common ticks well known from prior decades, including the rickettsial organism that causes Rocky Mountain Spotted Fever among others (usually not transmitted for 36 or more hours after attachment, allowing rapid removal to afford some safety).
This is by way of a longer explanation that among those ingredients in these new protective oral medications is Lotilaner, which kills the ticks quickly and has been shown to do so before Borrelia (Lyme Disease organism) can be transmitted, and probably, but not yet established, before Babesia (parasite that causes a potentially fatal anemia) can be transmitted.
So, Lotilaner is NOW likewise being evaluated in clinical trials for tick (and thus tick-borne Lyme Disease and Babesia prevention) in humans, and the safety profile and efficacy should be very good. This is a tremendous advancement if so (RFK Jr. and his idiots, notwithstanding). Vector-borne disease is going to be an intense health risk for ALL MAMMALS, including Humans, only worsening in the future.
https://clinicaltrials.gov/study/NCT05387083
A Human Tick Kill Study to Investigate the Safety, Tolerability, and Whole Blood Concentration of TP-05