The logic of vaccine mix n' match [View all]
Last week, the U.S. Food and Drug Administration and the Disease Control and Prevention authorized and recommended boosters of both the Moderna and Johnson & Johnson (J&J) COVID-19 vaccines. Modernas booster comes in just a half dose, and is recommended for people over 65, people over 50 with certain conditions, and people who work in high-exposure jobs. For J&J vaccine recipients, boosters were recommended for everyone over 18.
Though the CDC recommended that people boost with the vaccine they started with, they also endorsed a mix n match approach. This is particularly salient for Americans who received the J&J vaccine, considering its laggard performance in preventing breakthrough delta infections relative to its mRNA cousins.
Indeed, a recent National Institutes of Health study found that among people whose first vaccination was with J&J, receiving a second J&J dose led to a four-fold increase in antibody reactivity in a test tube. But boosting with Pfizer led to a 35-fold increase and boosting with Moderna led to a 76-fold increase.
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No data on booster after 2 Moderna vacs.